Epigenetic deregulation of lamina-associated domains in Hutchinson-Gilford progeria syndrome

BACKGROUND: Hutchinson-Gilford progeria syndrome (HGPS) is a progeroid disease characterized by the early onset of age-related phenotypes including arthritis, loss of body fat and hair, and atherosclerosis. Cells from affected individuals express a mutant version of the nuclear envelope protein lami...

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Detalhes bibliográficos
Publicado no:Genome Med
Main Authors: Köhler, Florian, Bormann, Felix, Raddatz, Günter, Gutekunst, Julian, Corless, Samuel, Musch, Tanja, Lonsdorf, Anke S., Erhardt, Sylvia, Lyko, Frank, Rodríguez-Paredes, Manuel
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
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Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7249329/
https://ncbi.nlm.nih.gov/pubmed/32450911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-020-00749-y
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