T cells translate individual, quantal activation into collective, analog cytokine responses via time-integrated feedbacks

Variability within isogenic T cell populations yields heterogeneous ‘local’ signaling responses to shared antigenic stimuli, but responding clones may communicate ‘global’ antigen load through paracrine messengers, such as cytokines. Such coordination of individual cell responses within multicellula...

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Detalhes bibliográficos
Main Authors: Tkach, Karen E, Barik, Debashis, Voisinne, Guillaume, Malandro, Nicole, Hathorn, Matthew M, Cotari, Jesse W, Vogel, Robert, Merghoub, Taha, Wolchok, Jedd, Krichevsky, Oleg, Altan-Bonnet, Grégoire
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2014
Assuntos:
Biophysics and Structural Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3980879/
https://ncbi.nlm.nih.gov/pubmed/24719192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.01944
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