Clonal Abundance of Tumor Specific CD4(+) T cells Potentiates Efficacy and Alters Susceptibility to Exhaustion

Current approaches to cancer immunotherapy aim to engage the natural T cell response against tumors. One limitation is the elimination of self-antigen specific T cells from the immune repertoire. Using a system in which precursor frequency can be manipulated in a murine melanoma model, we demonstrat...

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Vydáno v:Immunity
Hlavní autoři: Malandro, Nicole, Budhu, Sadna, Kuhn, Nicholas F., Liu, Cailian, Murphy, Judith T., Cortez, Czrina, Zhong, Hong, Yang, Xia, Rizzuto, Gabrielle, Altan-Bonnet, Grégoire, Merghoub, Taha, Wolchok, Jedd D.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4996670/
https://ncbi.nlm.nih.gov/pubmed/26789923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2015.12.018
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