MNK1-Induced eIF-4E Phosphorylation in Myeloma Cells: A Pathway Mediating IL-6-Induced Expansion and Expression of Genes Involved in Metabolic and Proteotoxic Responses

Because multiple myeloma (MM) cells are at risk for endoplasmic reticulum (ER) stress, they require a carefully regulated mechanism to promote protein translation of selected transcripts when proliferation is stimulated. MAPK-interacting kinases (MNKs) may provide this mechanism by enhancing cap-dep...

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Detalhes bibliográficos
Main Authors: Shi, Yijiang, Frost, Patrick, Hoang, Bao, Yang, Yonghui, Bardeleben, Carolyne, Gera, Joseph, Lichtenstein, Alan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3979714/
https://ncbi.nlm.nih.gov/pubmed/24714040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0094011
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