Myocardial Infarction-induced N-terminal Fragment of Cardiac Myosin-binding Protein C (cMyBP-C) Impairs Myofilament Function in Human Myocardium

Myocardial infarction (MI) is associated with depressed cardiac contractile function and progression to heart failure. Cardiac myosin-binding protein C, a cardiac-specific myofilament protein, is proteolyzed post-MI in humans, which results in an N-terminal fragment, C0-C1f. The presence of C0-C1f i...

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Autores principales: Witayavanitkul, Namthip, Ait Mou, Younss, Kuster, Diederik W. D., Khairallah, Ramzi J., Sarkey, Jason, Govindan, Suresh, Chen, Xin, Ge, Ying, Rajan, Sudarsan, Wieczorek, David F., Irving, Thomas, Westfall, Margaret V., de Tombe, Pieter P., Sadayappan, Sakthivel
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
Materias:
Molecular Bases of Disease
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3979389/
https://ncbi.nlm.nih.gov/pubmed/24509847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.541128
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