Cardiac Myosin-binding Protein C and Troponin-I Phosphorylation Independently Modulate Myofilament Length-dependent Activation

β-Adrenergic stimulation in heart leads to increased contractility and lusitropy via activation of protein kinase A (PKA). In the cardiac sarcomere, both cardiac myosin binding protein C (cMyBP-C) and troponin-I (cTnI) are prominent myofilament targets of PKA. Treatment of permeabilized myocardium w...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Biol Chem
Egile Nagusiak: Kumar, Mohit, Govindan, Suresh, Zhang, Mengjie, Khairallah, Ramzi J., Martin, Jody L., Sadayappan, Sakthivel, de Tombe, Pieter P.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2015
Gaiak:
Molecular Biophysics
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4705930/
https://ncbi.nlm.nih.gov/pubmed/26453301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.686790
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