Cardiac Myosin-binding Protein C and Troponin-I Phosphorylation Independently Modulate Myofilament Length-dependent Activation

β-Adrenergic stimulation in heart leads to increased contractility and lusitropy via activation of protein kinase A (PKA). In the cardiac sarcomere, both cardiac myosin binding protein C (cMyBP-C) and troponin-I (cTnI) are prominent myofilament targets of PKA. Treatment of permeabilized myocardium w...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Kumar, Mohit, Govindan, Suresh, Zhang, Mengjie, Khairallah, Ramzi J., Martin, Jody L., Sadayappan, Sakthivel, de Tombe, Pieter P.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Molecular Biophysics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4705930/
https://ncbi.nlm.nih.gov/pubmed/26453301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.686790
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