Restrictive Cardiomyopathy Troponin I R145W Mutation Does Not Perturb Myofilament Length-dependent Activation in Human Cardiac Sarcomeres

The cardiac troponin I (cTnI) R145W mutation is associated with restrictive cardiomyopathy (RCM). Recent evidence suggests that this mutation induces perturbed myofilament length-dependent activation (LDA) under conditions of maximal protein kinase A (PKA) stimulation. Some cardiac disease-causing m...

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Udgivet i:J Biol Chem
Main Authors: Dvornikov, Alexey V., Smolin, Nikolai, Zhang, Mengjie, Martin, Jody L., Robia, Seth L., de Tombe, Pieter P.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2016
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5076848/
https://ncbi.nlm.nih.gov/pubmed/27557662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.746172
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