Perturbed Length–Dependent Activation in Human Hypertrophic Cardiomyopathy With Missense Sarcomeric Gene Mutations

RATIONALE: High-myofilament Ca(2+)-sensitivity has been proposed as trigger of disease pathogenesis in familial hypertrophic cardiomyopathy (HCM) based on in vitro and transgenic mice studies. However, myofilament Ca(2+)-sensitivity depends on protein phosphorylation and muscle length, and at presen...

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Main Authors: Sequeira, Vasco, Wijnker, Paul J.M., Nijenkamp, Louise L.A.M., Kuster, Diederik W.D., Najafi, Aref, Witjas-Paalberends, E. Rosalie, Regan, Jessica A., Boontje, Nicky, ten Cate, Folkert J., Germans, Tjeerd, Carrier, Lucie, Sadayappan, Sakthivel, van Slegtenhorst, Marjon A., Zaremba, Ruud, Foster, D. Brian, Murphy, Anne M., Poggesi, Corrado, dos Remedios, Cris, Stienen, Ger J.M., Ho, Carolyn Y., Michels, Michelle, van der Velden, Jolanda
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3675884/
https://ncbi.nlm.nih.gov/pubmed/23508784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.111.300436
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