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Synthesis of isotopically labeled epothilones
The epothilones, including epothilones B and D, are macrocyclic lactones which have potent cytotoxicities and which promote the polymerization of tubulin to mictotubules by binding to and stabilizing the tubulin polymer. They have a very similar mechanism of action to paclitaxel (Taxol®). The determ...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3979290/ https://ncbi.nlm.nih.gov/pubmed/24307484 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jlcr.3144 |
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