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Mutational Analysis of Preamyloid Intermediates: The Role of His-Tyr Interactions in Islet Amyloid Formation

Islet amyloid polypeptide (IAPP or Amylin) is a 37-residue, C-terminally amidated pancreatic hormone, cosecreted with insulin that forms islet amyloid in type 2 diabetes. Islet amyloid formation is complex and characterizing preamyloid oligomers is an important topic because oligomeric intermediates...

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Bibliografiske detaljer
Main Authors: Tu, Ling-Hsien, Serrano, Arnaldo L., Zanni, Martin T., Raleigh, Daniel P.
Format: Artigo
Sprog:Inglês
Udgivet: The Biophysical Society 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3976524/
https://ncbi.nlm.nih.gov/pubmed/24703313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2013.12.052
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