A Free Energy Barrier Caused by the Refolding of an Oligomeric Intermediate Controls the Lag Time of Amyloid Formation by hIAPP

Transiently populated oligomers formed en route to amyloid fibrils may constitute the most toxic aggregates associated with many amyloid-associated diseases. Most nucleation theories used to describe amyloid aggregation predict low oligomer concentrations and do not take into account free energy cos...

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Bibliografiska uppgifter
I publikationen:J Am Chem Soc
Huvudupphovsmän: Serrano, Arnaldo L., Lomont, Justin P., Tu, Ling-Hsien, Raleigh, Daniel P., Zanni, Martin T.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2017
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5859135/
https://ncbi.nlm.nih.gov/pubmed/29072444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b08830
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