Mechanism of IAPP amyloid fibril formation involves an intermediate with a transient β-sheet

Amyloid formation is implicated in more than 20 human diseases, yet the mechanism by which fibrils form is not well understood. We use 2D infrared spectroscopy and isotope labeling to monitor the kinetics of fibril formation by human islet amyloid polypeptide (hIAPP or amylin) that is associated wit...

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Bibliografiska uppgifter
Huvudupphovsmän: Buchanan, Lauren E., Dunkelberger, Emily B., Tran, Huong Q., Cheng, Pin-Nan, Chiu, Chi-Cheng, Cao, Ping, Raleigh, Daniel P., de Pablo, Juan J., Nowick, James S., Zanni, Martin T.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2013
Ämnen:
Physical Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3845187/
https://ncbi.nlm.nih.gov/pubmed/24218609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1314481110
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