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Mechanism of IAPP amyloid fibril formation involves an intermediate with a transient β-sheet

Amyloid formation is implicated in more than 20 human diseases, yet the mechanism by which fibrils form is not well understood. We use 2D infrared spectroscopy and isotope labeling to monitor the kinetics of fibril formation by human islet amyloid polypeptide (hIAPP or amylin) that is associated wit...

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Bibliografiske detaljer
Main Authors: Buchanan, Lauren E., Dunkelberger, Emily B., Tran, Huong Q., Cheng, Pin-Nan, Chiu, Chi-Cheng, Cao, Ping, Raleigh, Daniel P., de Pablo, Juan J., Nowick, James S., Zanni, Martin T.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3845187/
https://ncbi.nlm.nih.gov/pubmed/24218609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1314481110
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