HDAC inhibitors enhance the lethality of low dose salinomycin in parental and stem-like GBM cells

The present studies determined whether the antibiotic salinomycin interacted with HDAC inhibitors to kill primary human GBM cells. Regardless of PTEN, ERBB1, or p53 mutational status salinomycin interacted with HDAC inhibitors in a synergistic fashion to kill GBM cells. Inhibition of CD95/Caspase 8...

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Main Authors: Booth, Laurence, Roberts, Jane L, Conley, Adam, Cruickshanks, Nichola, Ridder, Thomas, Grant, Steven, Poklepovic, Andrew, Dent, Paul
格式: Artigo
語言:Inglês
出版: Landes Bioscience 2014
主題:
Research Paper
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3974832/
https://ncbi.nlm.nih.gov/pubmed/24351423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.27309
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