CpG domains downstream of TSSs promote high levels of gene expression

CpG dinucleotides are known to play a crucial role in regulatory domains, affecting gene expression in their natural context. Here, we demonstrate that intragenic CpG frequency and distribution impacts transgene and genomic gene expression levels in mammalian cells. As shown for the Macrophage Infla...

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Bibliographic Details
Main Authors: Krinner, Simone, Heitzer, Asli P., Diermeier, Sarah D., Obermeier, Ingrid, Längst, Gernot, Wagner, Ralf
Format: Artigo
Language:Inglês
Published: Oxford University Press 2014
Subjects:
Gene Regulation, Chromatin and Epigenetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973331/
https://ncbi.nlm.nih.gov/pubmed/24413563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt1358
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