CpG domains downstream of TSSs promote high levels of gene expression

CpG dinucleotides are known to play a crucial role in regulatory domains, affecting gene expression in their natural context. Here, we demonstrate that intragenic CpG frequency and distribution impacts transgene and genomic gene expression levels in mammalian cells. As shown for the Macrophage Infla...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Krinner, Simone, Heitzer, Asli P., Diermeier, Sarah D., Obermeier, Ingrid, Längst, Gernot, Wagner, Ralf
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2014
Aiheet:
Gene Regulation, Chromatin and Epigenetics
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973331/
https://ncbi.nlm.nih.gov/pubmed/24413563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt1358
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