CpG domains downstream of TSSs promote high levels of gene expression

CpG dinucleotides are known to play a crucial role in regulatory domains, affecting gene expression in their natural context. Here, we demonstrate that intragenic CpG frequency and distribution impacts transgene and genomic gene expression levels in mammalian cells. As shown for the Macrophage Infla...

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Main Authors: Krinner, Simone, Heitzer, Asli P., Diermeier, Sarah D., Obermeier, Ingrid, Längst, Gernot, Wagner, Ralf
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2014
Assuntos:
Gene Regulation, Chromatin and Epigenetics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973331/
https://ncbi.nlm.nih.gov/pubmed/24413563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt1358
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