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DNA methylation in human epigenomes depends on local topology of CpG sites

In vertebrates, methylation of cytosine at CpG sequences is implicated in stable and heritable patterns of gene expression. The classical model for inheritance, in which individual CpG sites are independent, provides no explanation for the observed non-random patterns of methylation. We first invest...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Lövkvist, Cecilia, Dodd, Ian B., Sneppen, Kim, Haerter, Jan O.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4914085/
https://ncbi.nlm.nih.gov/pubmed/26932361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw124
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