Differences in DNA methylation between human neuronal and glial cells are concentrated in enhancers and non-CpG sites

We applied Illumina Human Methylation450K array to perform a genomic-scale single-site resolution DNA methylation analysis in neuronal and nonneuronal (primarily glial) nuclei separated from the orbitofrontal cortex of postmortem human brain. The findings were validated using enhanced reduced repres...

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Detalhes bibliográficos
Main Authors: Kozlenkov, Alexey, Roussos, Panos, Timashpolsky, Alisa, Barbu, Mihaela, Rudchenko, Sergei, Bibikova, Marina, Klotzle, Brandy, Byne, William, Lyddon, Rebecca, Di Narzo, Antonio Fabio, Hurd, Yasmin L., Koonin, Eugene V., Dracheva, Stella
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
Gene Regulation, Chromatin and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3874157/
https://ncbi.nlm.nih.gov/pubmed/24057217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt838
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