CpG domains downstream of TSSs promote high levels of gene expression

CpG dinucleotides are known to play a crucial role in regulatory domains, affecting gene expression in their natural context. Here, we demonstrate that intragenic CpG frequency and distribution impacts transgene and genomic gene expression levels in mammalian cells. As shown for the Macrophage Infla...

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Detaylı Bibliyografya
Asıl Yazarlar: Krinner, Simone, Heitzer, Asli P., Diermeier, Sarah D., Obermeier, Ingrid, Längst, Gernot, Wagner, Ralf
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2014
Konular:
Gene Regulation, Chromatin and Epigenetics
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973331/
https://ncbi.nlm.nih.gov/pubmed/24413563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt1358
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