CpG domains downstream of TSSs promote high levels of gene expression

CpG dinucleotides are known to play a crucial role in regulatory domains, affecting gene expression in their natural context. Here, we demonstrate that intragenic CpG frequency and distribution impacts transgene and genomic gene expression levels in mammalian cells. As shown for the Macrophage Infla...

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Bibliografiske detaljer
Main Authors: Krinner, Simone, Heitzer, Asli P., Diermeier, Sarah D., Obermeier, Ingrid, Längst, Gernot, Wagner, Ralf
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2014
Fag:
Gene Regulation, Chromatin and Epigenetics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973331/
https://ncbi.nlm.nih.gov/pubmed/24413563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt1358
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