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Checkpoint kinase 1 negatively regulates somatic hypermutation
Immunoglobulin (Ig) diversification by somatic hypermutation in germinal center B cells is instrumental for maturation of the humoral immune response, but also bears the risk of excessive or aberrant genetic changes. Thus, introduction of DNA damage by activation-induced cytidine deaminase as well a...
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| मुख्य लेखकों: | , , , , , , |
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| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
Oxford University Press
2014
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3973322/ https://ncbi.nlm.nih.gov/pubmed/24423870 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt1378 |
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