Restriction of AID activity and somatic hypermutation by PARP-1

Affinity maturation of the humoral immune response depends on somatic hypermutation (SHM) of immunoglobulin (Ig) genes, which is initiated by targeted lesion introduction by activation-induced deaminase (AID), followed by error-prone DNA repair. Stringent regulation of this process is essential to p...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Tepper, Sandra, Mortusewicz, Oliver, Członka, Ewelina, Bello, Amanda, Schmidt, Angelika, Jeschke, Julia, Fischbach, Arthur, Pfeil, Ines, Petersen-Mahrt, Svend K, Mangerich, Aswin, Helleday, Thomas, Leonhardt, Heinrich, Jungnickel, Berit
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6698665/
https://ncbi.nlm.nih.gov/pubmed/31127309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz466
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