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Involvement of Rad18 in somatic hypermutation

Somatic hypermutation of Ig genes is initiated by transcription-coupled cytidine deamination in Ig loci. Error-prone processing of the resultant DNA lesions is thought to cause extensive mutagenesis, but it is presently an enigma how and why error-prone rather than error-free repair pathways are rec...

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Bibliografiska uppgifter
Huvudupphovsmän: Bachl, Jürgen, Ertongur, Isin, Jungnickel, Berit
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2006
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1567700/
https://ncbi.nlm.nih.gov/pubmed/16873544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0605146103
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