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Ubc13 dosage is critical for immunoglobulin gene conversion and gene targeting in vertebrate cells
In contrast to lower eukaryotes, most vertebrate cells are characterized by a moderate efficiency of homologous recombination (HR) and limited feasibility of targeted genetic modifications. As a notable exception, the chicken DT40 B cell line is distinguished by efficient homology-mediated repair of...
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| Main Authors: | , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
Oxford University Press
2010
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2919702/ https://ncbi.nlm.nih.gov/pubmed/20223767 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq154 |
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