Checkpoint kinase 1 negatively regulates somatic hypermutation

Immunoglobulin (Ig) diversification by somatic hypermutation in germinal center B cells is instrumental for maturation of the humoral immune response, but also bears the risk of excessive or aberrant genetic changes. Thus, introduction of DNA damage by activation-induced cytidine deaminase as well a...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Frankenberger, Samantha, Davari, Kathrin, Fischer-Burkart, Sabine, Böttcher, Katrin, Tomi, Nils-Sebastian, Zimber-Strobl, Ursula, Jungnickel, Berit
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2014
Schlagworte:
Genome Integrity, Repair and Replication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973322/
https://ncbi.nlm.nih.gov/pubmed/24423870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt1378
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