Novel Pathways to Erythropoiesis Induced by Dimerization of Intracellular c-Mpl in Human Hematopoietic Progenitors

The cytokine thrombopoietin (Tpo) plays a critical role in hematopoiesis by binding to the extracellular domain and inducing homodimerization of the intracellular signaling domain of its receptor, c-Mpl. Mpl homodimerization can also be accomplished by binding of a synthetic ligand to a constitutive...

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Hauptverfasser: PAREKH, CHINTAN, SAHAGHIAN, ARINEH, KIM, WILLIAM, SCHOLES, JESSICA, GE, SHUNDI, ZHU, YUHUA, ASGHARZADEH, SHAHAB, HOLLIS, ROGER, KOHN, DONALD, JI, LINGYUN, MALVAR, JEMILY, WANG, XIAOYAN, CROOKS, GAY
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973153/
https://ncbi.nlm.nih.gov/pubmed/22290824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.1046
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