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Novel Pathways to Erythropoiesis Induced by Dimerization of Intracellular c-Mpl in Human Hematopoietic Progenitors
The cytokine thrombopoietin (Tpo) plays a critical role in hematopoiesis by binding to the extracellular domain and inducing homodimerization of the intracellular signaling domain of its receptor, c-Mpl. Mpl homodimerization can also be accomplished by binding of a synthetic ligand to a constitutive...
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| Main Authors: | , , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3973153/ https://ncbi.nlm.nih.gov/pubmed/22290824 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.1046 |
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