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Expansion of multipotent and lymphoid-committed human progenitors through intracellular dimerization of Mpl

Self-renewal capacity is rapidly lost during differentiation of hematopoietic stem cells to lineage-committed progenitors. We demonstrate here that regulated intracellular signaling through the cytokine receptor Mpl induces profound expansion of not only multipotent (ie, lymphomyeloid) but also lymp...

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Detalhes bibliográficos
Main Authors: Abdel-Azim, Hisham, Zhu, Yuhua, Hollis, Roger, Wang, Xiuli, Ge, Shundi, Hao, Qian-Lin, Smbatyan, Goar, Kohn, Donald B., Rosol, Michael, Crooks, Gay M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2288719/
https://ncbi.nlm.nih.gov/pubmed/18174381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-08-107466
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