Innate Immune Protection against Infectious Diseases by Pulmonary Administration of a Phospholipid-Conjugated TLR7 Ligand

Pulmonary administration of Toll-like receptor (TLR) ligands protects hosts from inhaled pathogens. However, systemic side effects induced by TLR stimulation limit clinical development. Here, a small-molecule TLR7 ligand conjugated with phospholipid, 1V270 (also designated TMX201), was tested for in...

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Bibliografische gegevens
Hoofdauteurs: Wu, Christina C.N., Crain, Brian, Yao, Shiyin, Sabet, Mojgan, Lao, Fitzgerald S., Tawatao, Rommel I., Chan, Michael, Smee, Donald F., Julander, Justin G., Cottam, Howard B., Guiney, Donald G., Corr, Maripat, Carson, Dennis A., Hayashi, Tomoko
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: S. Karger AG 2014
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3972367/
https://ncbi.nlm.nih.gov/pubmed/24192551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000355217
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