Innate Immune Protection against Infectious Diseases by Pulmonary Administration of a Phospholipid-Conjugated TLR7 Ligand

Pulmonary administration of Toll-like receptor (TLR) ligands protects hosts from inhaled pathogens. However, systemic side effects induced by TLR stimulation limit clinical development. Here, a small-molecule TLR7 ligand conjugated with phospholipid, 1V270 (also designated TMX201), was tested for in...

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Hlavní autoři: Wu, Christina C.N., Crain, Brian, Yao, Shiyin, Sabet, Mojgan, Lao, Fitzgerald S., Tawatao, Rommel I., Chan, Michael, Smee, Donald F., Julander, Justin G., Cottam, Howard B., Guiney, Donald G., Corr, Maripat, Carson, Dennis A., Hayashi, Tomoko
Médium: Artigo
Jazyk:Inglês
Vydáno: S. Karger AG 2014
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3972367/
https://ncbi.nlm.nih.gov/pubmed/24192551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000355217
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