Innate Immune Protection against Infectious Diseases by Pulmonary Administration of a Phospholipid-Conjugated TLR7 Ligand

Pulmonary administration of Toll-like receptor (TLR) ligands protects hosts from inhaled pathogens. However, systemic side effects induced by TLR stimulation limit clinical development. Here, a small-molecule TLR7 ligand conjugated with phospholipid, 1V270 (also designated TMX201), was tested for in...

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Detalhes bibliográficos
Main Authors: Wu, Christina C.N., Crain, Brian, Yao, Shiyin, Sabet, Mojgan, Lao, Fitzgerald S., Tawatao, Rommel I., Chan, Michael, Smee, Donald F., Julander, Justin G., Cottam, Howard B., Guiney, Donald G., Corr, Maripat, Carson, Dennis A., Hayashi, Tomoko
Formato: Artigo
Idioma:Inglês
Publicado em: S. Karger AG 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3972367/
https://ncbi.nlm.nih.gov/pubmed/24192551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000355217
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