Lataa...

IN VIVO EFFICACY OF A PHOSPHODIESTER TLR-9 APTAMER AND ITS BENEFICIAL EFFECT IN A PULMANARY ANTHRAX INFECTION MODEL

Immunostimulatory oligonucleotide (ISS-ODN) used as adjuvants are commonly modified with phosphorothioate (PS). The PS backbone prevents nuclease degradation, but confers undesired side effects, including systemic cytokine release. Previously, R10-60, a phosphodiester (PO) ISS-ODN, was structurally...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Wu, Christina C.N., Sabet, Mojgan, Hayashi, Tomoko, Tawatao, Rommel, Fierer, Joshua, Carson, Dennis A., Guiney, Donald G., Corr, Maripat
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2008
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4012540/
https://ncbi.nlm.nih.gov/pubmed/18495099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellimm.2008.04.001
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!