IN VIVO EFFICACY OF A PHOSPHODIESTER TLR-9 APTAMER AND ITS BENEFICIAL EFFECT IN A PULMANARY ANTHRAX INFECTION MODEL

Immunostimulatory oligonucleotide (ISS-ODN) used as adjuvants are commonly modified with phosphorothioate (PS). The PS backbone prevents nuclease degradation, but confers undesired side effects, including systemic cytokine release. Previously, R10-60, a phosphodiester (PO) ISS-ODN, was structurally...

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Autores principales: Wu, Christina C.N., Sabet, Mojgan, Hayashi, Tomoko, Tawatao, Rommel, Fierer, Joshua, Carson, Dennis A., Guiney, Donald G., Corr, Maripat
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4012540/
https://ncbi.nlm.nih.gov/pubmed/18495099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellimm.2008.04.001
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