Treatment of Autoimmune Inflammation by a TLR7 Ligand Regulating the Innate Immune System

The Toll-like receptors (TLR) have been advocated as attractive therapeutic targets because TLR signaling plays dual roles in initiating adaptive immune responses and perpetuating inflammation. Paradoxically, repeated stimulation of bone marrow mononuclear cells with a synthetic TLR7 ligand 9-benzyl...

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Hlavní autoři: Hayashi, Tomoko, Yao, Shiyin, Crain, Brian, Chan, Michael, Tawatao, Rommel I., Gray, Christine, Vuong, Linda, Lao, Fitzgerald, Cottam, Howard B., Carson, Dennis A., Corr, Maripat
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2012
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3461028/
https://ncbi.nlm.nih.gov/pubmed/23029281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0045860
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