Targeting the Transposase Domain of the DNA Repair Component Metnase to Enhance Chemotherapy

Previous studies have shown that the DNA repair component Metnase (SETMAR) mediates resistance to DNA damaging cancer chemotherapy. Metnase has a nuclease domain that shares homology with the Transposase family. We therefore virtually screened the tertiary Metnase structure against the 550,000 compo...

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Bibliografiske detaljer
Main Authors: Williamson, Elizabeth A., Damiani, Leah, Leitao, Andrei, Hu, Chelin, Hathaway, Helen, Oprea, Tudor, Sklar, Larry, Shaheen, Montaser, Bauman, Julie, Wang, Wei, Nickoloff, Jac A., Lee, Suk-Hee, Hromas, Robert
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3972061/
https://ncbi.nlm.nih.gov/pubmed/23090115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-0313
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