Targeting the Transposase Domain of the DNA Repair Component Metnase to Enhance Chemotherapy

Previous studies have shown that the DNA repair component Metnase (SETMAR) mediates resistance to DNA damaging cancer chemotherapy. Metnase has a nuclease domain that shares homology with the Transposase family. We therefore virtually screened the tertiary Metnase structure against the 550,000 compo...

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Autori principali: Williamson, Elizabeth A., Damiani, Leah, Leitao, Andrei, Hu, Chelin, Hathaway, Helen, Oprea, Tudor, Sklar, Larry, Shaheen, Montaser, Bauman, Julie, Wang, Wei, Nickoloff, Jac A., Lee, Suk-Hee, Hromas, Robert
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3972061/
https://ncbi.nlm.nih.gov/pubmed/23090115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-0313
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