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Structure-Activity Relationship Studies and Biological Characterization of Human NAD(+)-dependent 15-Hydroxyprostaglandin Dehydrogenase Inhibitors
The structure-activity relationship (SAR) study of two chemotypes identified as inhibitors of the human NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase (HPGD, 15-PGDH) was conducted. Top compounds from both series displayed potent inhibition (IC(50) <50 nM), demonstrate excellent selectivi...
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| Main Authors: | , , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2013
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3970110/ https://ncbi.nlm.nih.gov/pubmed/24360556 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.11.081 |
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