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Bile acids inhibit NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase transcription in colonocytes
Multiple lines of evidence have suggested a role for both bile acids and prostaglandins (PG) in gastrointestinal carcinogenesis. Levels of PGE(2) are determined by both synthesis and catabolism. Previously, bile acid-mediated induction of cyclooxygenase-2 (COX-2) was found to stimulate PGE(2) synthe...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2739822/ https://ncbi.nlm.nih.gov/pubmed/19608733 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00133.2009 |
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