Bile acids inhibit NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase transcription in colonocytes

Multiple lines of evidence have suggested a role for both bile acids and prostaglandins (PG) in gastrointestinal carcinogenesis. Levels of PGE(2) are determined by both synthesis and catabolism. Previously, bile acid-mediated induction of cyclooxygenase-2 (COX-2) was found to stimulate PGE(2) synthe...

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Detaylı Bibliyografya
Asıl Yazarlar: Miyaki, Akira, Yang, Peiying, Tai, Hsin-Hsiung, Subbaramaiah, Kotha, Dannenberg, Andrew J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Physiological Society 2009
Konular:
Inflammation/Immunity/Mediators
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2739822/
https://ncbi.nlm.nih.gov/pubmed/19608733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00133.2009
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