Pioglitazone, a PPARγ Agonist, Suppresses CYP19 Transcription: Evidence for Involvement of 15-Hydroxyprostaglandin Dehydrogenase and BRCA1

Estrogen synthesis is catalyzed by cytochrome P450 aromatase, which is encoded by the CYP19 gene. In obese postmenopausal women, increased aromatase activity in white adipose tissue is believed to contribute to hormone-dependent breast cancer. Prostaglandin E(2) (PGE(2)) stimulates the cAMP→protein...

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Detalhes bibliográficos
Main Authors: Subbaramaiah, Kotha, Howe, Louise R., Zhou, Xi Kathy, Yang, Peiying, Hudis, Clifford A., Kopelovich, Levy, Dannenberg, Andrew J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3694442/
https://ncbi.nlm.nih.gov/pubmed/22787115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-12-0201
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