Structure-Activity Relationship Studies and Biological Characterization of Human NAD(+)-dependent 15-Hydroxyprostaglandin Dehydrogenase Inhibitors

The structure-activity relationship (SAR) study of two chemotypes identified as inhibitors of the human NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase (HPGD, 15-PGDH) was conducted. Top compounds from both series displayed potent inhibition (IC(50) <50 nM), demonstrate excellent selectivi...

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Hauptverfasser: Duveau, Damien Y., Yasgar, Adam, Wang, Yuhong, Hu, Xin, Kouznetsova, Jennifer, Brimacombe, Kyle R., Jadhav, Ajit, Simeonov, Anton, Thomas, Craig J., Maloney, David J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3970110/
https://ncbi.nlm.nih.gov/pubmed/24360556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.11.081
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