A potent and Kv1.3-selective analogue of the scorpion toxin HsTX1 as a potential therapeutic for autoimmune diseases

HsTX1 toxin, from the scorpion Heterometrus spinnifer, is a 34-residue, C-terminally amidated peptide cross-linked by four disulfide bridges. Here we describe new HsTX1 analogues with an Ala, Phe, Val or Abu substitution at position 14. Complexes of HsTX1 with the voltage-gated potassium channels Kv...

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Detalhes bibliográficos
Main Authors: Rashid, M. Harunur, Huq, Redwan, Tanner, Mark R., Chhabra, Sandeep, Khoo, Keith K., Estrada, Rosendo, Dhawan, Vikas, Chauhan, Satendra, Pennington, Michael W., Beeton, Christine, Kuyucak, Serdar, Norton, Raymond S.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3968461/
https://ncbi.nlm.nih.gov/pubmed/24676092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep04509
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