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Largazole Pharmacokinetics in Rats by LC-MS/MS
A highly sensitive and specific LC-MS/MS method for the quantitation of largazole thiol, the active species of the marine-derived preclinical histone deacetylase inhibitor, largazole (prodrug), was developed and validated. Largazole thiol was extracted with ethyl acetate from human or rat plasma alo...
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| Main Authors: | , , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
MDPI
2014
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3967229/ https://ncbi.nlm.nih.gov/pubmed/24658499 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md12031623 |
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