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Redesign of extensive protein–DNA interfaces of meganucleases using iterative cycles of in vitro compartmentalization
LAGLIDADG homing endonucleases (meganucleases) are sequence-specific DNA cleavage enzymes used for genome engineering. Recently, meganucleases fused to transcription activator-like effectors have been demonstrated to efficiently introduce targeted genome modifications. However, retargeting meganucle...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3964072/ https://ncbi.nlm.nih.gov/pubmed/24591643 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1321030111 |
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