Redesigning an FKBP–ligand interface to generate chemical dimerizers with novel specificity

FKBP ligand homodimers can be used to activate signaling events inside cells and animals that have been engineered to express fusions between appropriate signaling domains and FKBP. However, use of these dimerizers in vivo is potentially limited by ligand binding to endogenous FKBP. We have designed...

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Autors principals: Clackson, Tim, Yang, Wu, Rozamus, Leonard W., Hatada, Marcos, Amara, Jane F., Rollins, Carl T., Stevenson, Lauren F., Magari, Shannon R., Wood, Susan A., Courage, Nancy L., Lu, Xiaode, Cerasoli, Franklin, Gilman, Michael, Holt, Dennis A.
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 1998
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC27912/
https://ncbi.nlm.nih.gov/pubmed/9724721
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