Redesigning an FKBP–ligand interface to generate chemical dimerizers with novel specificity

FKBP ligand homodimers can be used to activate signaling events inside cells and animals that have been engineered to express fusions between appropriate signaling domains and FKBP. However, use of these dimerizers in vivo is potentially limited by ligand binding to endogenous FKBP. We have designed...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Clackson, Tim, Yang, Wu, Rozamus, Leonard W., Hatada, Marcos, Amara, Jane F., Rollins, Carl T., Stevenson, Lauren F., Magari, Shannon R., Wood, Susan A., Courage, Nancy L., Lu, Xiaode, Cerasoli, Franklin, Gilman, Michael, Holt, Dennis A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The National Academy of Sciences 1998
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC27912/
https://ncbi.nlm.nih.gov/pubmed/9724721
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg