Redesigning an FKBP–ligand interface to generate chemical dimerizers with novel specificity

FKBP ligand homodimers can be used to activate signaling events inside cells and animals that have been engineered to express fusions between appropriate signaling domains and FKBP. However, use of these dimerizers in vivo is potentially limited by ligand binding to endogenous FKBP. We have designed...

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Detalles Bibliográficos

Publicado en:	Proc Natl Acad Sci U S A
Principais autores:	Clackson, Tim, Yang, Wu, Rozamus, Leonard W., Hatada, Marcos, Amara, Jane F., Rollins, Carl T., Stevenson, Lauren F., Magari, Shannon R., Wood, Susan A., Courage, Nancy L., Lu, Xiaode, Cerasoli, Franklin, Gilman, Michael, Holt, Dennis A.
Formato:	Artigo
Idioma:	Inglês
Publicado:	National Academy of Sciences 1998
Assuntos:	Biological Sciences
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC27912/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9724721/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.18.10437
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