Prostate Cancer Induced by Loss of Apc Is Restrained by TGFβ Signaling

Recent work with mouse models of prostate cancer (CaP) has shown that inactivation of TGFβ signaling in prostate epithelium can cooperate with deletion of the Pten tumor suppressor to drive locally aggressive cancer and metastatic disease. Here, we show that inactivating the TGFβ pathway by deleting...

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Autors principals: Bjerke, Glen A., Pietrzak, Karolina, Melhuish, Tiffany A., Frierson Jr., Henry F., Paschal, Bryce M., Wotton, David
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3961420/
https://ncbi.nlm.nih.gov/pubmed/24651496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0092800
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