Activation of Akt Signaling in Prostate Induces a TGFβ Mediated Restraint on Cancer Progression and Metastasis

Mutations in the PTEN tumor suppressor gene are found in a high proportion of human prostate cancers, and in mice, Pten deletion induces high-grade prostate intra-epithelial neoplasia (HGPIN). However, progression from HGPIN to invasive cancer occurs slowly, suggesting that tumorigenesis is subject...

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Main Authors: Bjerke, Glen A., Yang, Chun-Song, Frierson, Henry F., Paschal, Bryce M., Wotton, David
格式: Artigo
語言:Inglês
出版: 2013
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3939071/
https://ncbi.nlm.nih.gov/pubmed/23995785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.342
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