TGFβ signaling limits lineage plasticity in prostate cancer

Although treatment options for localized prostate cancer (CaP) are initially effective, the five-year survival for metastatic CaP is below 30%. Mutation or deletion of the PTEN tumor suppressor is a frequent event in metastatic CaP, and inactivation of the transforming growth factor (TGF) ß signalin...

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Pubblicato in:PLoS Genet
Autori principali: Hao, Yi, Bjerke, Glen A., Pietrzak, Karolina, Melhuish, Tiffany A., Han, Yu, Turner, Stephen D., Frierson, Henry F., Wotton, David
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5983872/
https://ncbi.nlm.nih.gov/pubmed/29782499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007409
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