Redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis

The ability to redesign enzymes to catalyze non-cognate chemical transformations would have wide-ranging applications. We developed a computational method for repurposing the reactivity of active site functional groups of metalloenzymes to catalyze new reactions. Using this method, we engineered a z...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Khare, Sagar D., Kipnis, Yakov, Greisen, Per, Takeuchi, Ryo, Ashani, Yacov, Goldsmith, Moshe, Song, Yifan, Gallaher, Jasmine L., Silman, Israel, Leader, Haim, Sussman, Joel L., Stoddard, Barry L., Tawfik, Dan S., Baker, David
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2012
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3957331/
https://ncbi.nlm.nih.gov/pubmed/22306579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.777
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia