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Redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis
The ability to redesign enzymes to catalyze non-cognate chemical transformations would have wide-ranging applications. We developed a computational method for repurposing the reactivity of active site functional groups of metalloenzymes to catalyze new reactions. Using this method, we engineered a z...
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| Main Authors: | , , , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3957331/ https://ncbi.nlm.nih.gov/pubmed/22306579 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.777 |
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