Synergistic Targeting of AML Stem/Progenitor Cells With IAP Antagonist Birinapant and Demethylating Agents

BACKGROUND: Acute myeloid leukemia (AML) therapy has limited long-term efficacy because patients frequently develop disease relapse because of the inability of standard chemotherapeutic agents to target AML stem/progenitor cells. Here, we identify deregulated apoptotic components in AML stem/progeni...

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Detalhes bibliográficos
Main Authors: Carter, Bing Z., Mak, Po Yee, Mak, Duncan H., Shi, Yuexi, Qiu, Yihua, Bogenberger, James M., Mu, Hong, Tibes, Raoul, Yao, Hui, Coombes, Kevin R., Jacamo, Rodrigo O., McQueen, Teresa, Kornblau, Steven M., Andreeff, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3952202/
https://ncbi.nlm.nih.gov/pubmed/24526787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djt440
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