Apoptosis repressor with caspase recruitment domain is regulated by MAPK/PI3K and confers drug resistance and survival advantage to AML

The apoptosis repressor with caspase recruitment domain (ARC) protein is known to suppress both intrinsic and extrinsic apoptosis. We previously reported that ARC expression is a strong, independent adverse prognostic factor in acute myeloid leukemia (AML). Here, we investigated the regulation and r...

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Hauptverfasser: Mak, P. Y., Mak, D. H., Mu, H., Shi, Y., Ruvolo, P., Ruvolo, V., Jacamo, R., Burks, J. K., Wei, W., Huang, X., Kornblau, S. M., Andreeff, M., Carter, B. Z.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3943601/
https://ncbi.nlm.nih.gov/pubmed/24337870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10495-013-0954-z
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