An ARC-regulated IL1β/Cox-2/PGE2/β-catenin/ARC circuit controls leukemia-microenvironment interactions and confers drug resistance in AML

The apoptosis repressor with caspase recruitment domain (ARC) protein is a strong independent adverse prognostic marker in acute myeloid leukemia (AML). We previously reported that ARC regulates leukemia-microenvironment interactions through the NFkB/IL1β signaling network. Malignant cells have been...

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Veröffentlicht in:Cancer Res
Hauptverfasser: Carter, Bing Z., Mak, Po Yee, Wang, Xiangmeng, Tao, Wenjing, Ruvolo, Vivian, Mak, Duncan, Mu, Hong, Burks, Jared K., Andreeff, Michael
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6420856/
https://ncbi.nlm.nih.gov/pubmed/30674535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-0921
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